Regional Differences in Human Intestinal Drug Metabolism
نویسندگان
چکیده
منابع مشابه
Ethnic differences in drug metabolism.
Ethnic differences in drug metabolism are well documented for a number of drugs. The molecular mechanisms responsible for ethnic differences in drug metabolism have been partly clarified because of the advances in molecular biology in recent years. Gene dosage determines the drug metabolism as demonstrated for S-mephenytoin and diazepam metabolism. Genotype analysis indicates a different freque...
متن کاملGut instincts: CYP3A4 and intestinal drug metabolism.
First-pass metabolism is a common cause of incomplete and variable absolute bioavailability for an orally dosed drug. The drug-metabolizing enzyme CYP3A4 is often implicated in this process, resulting, in some cases, in systemic exposures of less than 15% of the administered dose. By creating an elegant CYP3A4-transgenic mouse model, van Herwaarden et al. show in this issue of the JCI that firs...
متن کاملInteraction between Intestinal Microbiota and Serotonin Metabolism
Gut microbiota regulates the production of signaling molecules, such as serotonin or 5-Hydroxytryptamine: 5-HT in the host. Serotonin is a biogenic amine that acts as a neurotransmitter in the gut and brain. There is a perfect interaction between human gastrointestinal microbiota and the serotonin system. The gut microbiota plays an important role in the serotonin signaling pathways through the...
متن کاملDifferences in Intestinal Absorptive Capacity of Chickens for D-Xylose
Background: According to literature, there are differences among different species of animals in respect to absorption of D-xylose. OBJECTIVES: In two experiments, the differences that might exist in absorptive capacity of small intestine for D-xylose, in different types of chicken were tested. METHODS: In experiment one, 2 groups of nine adult layer type males (48 weeks) and females (58 weeks)...
متن کاملRegional Economic Differences in Iran Theory and Evidence
Increasing concern over the regional dimensions of national economic planning since 1970s, has constituted appropriate baselines for scientific analysis of regional differences The Iranian planning views in the pre and post revolution era have been examined in this article, based on both theoretical and applied study of regional differences. Then the types and degrees of convergency and/or dive...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2018
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.118.083428